At this point, WPIX might have to go back to news at 5-9 am and 10 pm only. The saturated 5-7pm slot is already dominated by WABC, WNBC, and WCBS, who all have basically identically formatted newscasts.
WPIX has always been a standout in the mornings and at 10. With Greg Kelly out at GDNY for about a year now, better graphics, a better set, and maybe (another major overhaul in the mornings) might give them a boost. A massive move would be to improve their street side studio at Barclays Center and do a Today plaza styled show. GDNY did this well when they went live from Times Sq for the super bowl.
Likewise, a Jim Watkins/Kaity Tong 10pm reunion would be awesome and well overdue. WNBC pushed Sue Simmons out and hasn't had a solid replacement for her since. Just like WPIX pushed Watkins and Tong out for Applegate and we've had musical chairs at the anchor desk ever since.